He maha ngā wā ka āwhina te whakaahua hauora ki te tautuhi me te rongoā i ngā tipu matepukupuku. Ina koa, he whānui te whakamahinga o te whakaahua aukume (MRI) nā tōna kounga teitei, inā koa me ngā rongoā rerekē.
E ai ki tētahi rangahau hou i whakaputaina i roto i te puka Advanced Science, he rongoā rerekētanga nano-tauine hou e taea ai te whakapiko i a ia anō, ā, ka āwhina pea tēnei ki te tiro taipitopito atu i ngā pukupuku mā te MRI.
He aha te rerekētangapāpāho?
Ko ngā matū whakahāngai (e mōhiotia ana ko ngā matū whakahāngai) he matū e werohia ana (e tangohia rānei) ki roto i ngā kiko tangata, ki ngā whekau rānei hei whakarei ake i te mātakitaki whakaahua. He matotoru ake, he iti iho rānei ēnei whakaritenga i te kiko e karapoti ana, ka hangaia he whakahāngai e whakamahia ana hei whakaatu whakaahua me ētahi taputapu. Hei tauira, ko ngā whakaritenga iodine, te barium sulfate, me ētahi atu e whakamahia whānuitia ana mō te mātakitaki hihi-X. Ka werohia ki roto i te uaua toto o te tūroro mā te werohanga whakahāngai pēhanga teitei.
I te ine nano, ka roa te noho o ngā ngota ngota i roto i te toto, ā, ka taea te uru ki ngā pukupuku totoka me te kore e whakaoho i ngā tikanga karo ārai mate motuhake ki te pukupuku. He maha ngā matatini ngota ngota i runga i ngā nanomolecules kua rangahaua hei kawe pea i te CA ki roto i ngā pukupuku.
Me tohatoha tika ēnei kaihoko rerekētanga nano (NCA) i waenga i te toto me te kiko e hiahiatia ana kia whakaitihia ai te haruru papamuri me te whakatutuki i te ōwehenga tohu-ki-haruru teitei (S/N). I ngā kukū tiketike, ka noho tonu te NCA i roto i te toto mō ngā wā roa, ā, ka piki ake te mōrearea o te fibrosis whānui nā te tukunga o ngā katote gadolinium mai i te matatini.
Engari, ko te nuinga o ngā NCA e whakamahia ana i tēnei wā kei roto ngā huihuinga o ngā momo ngota rerekē. Ki raro iho i tētahi paepae, ka wehea ēnei micelle, ēnei tāpua rānei, ā, kāore i te mārama te putanga o tēnei huihuinga.
Nā tēnei i whakaoho te rangahau mō ngā macromolecules nano-tauine e takai ana i a rātou anō, kāore he paepae wehewehe matua. Kei roto i ēnei he uho ngako me te paparanga o waho wairewa e whakawhāiti ana i te nekehanga o ngā waeine wairewa puta noa i te mata pa. Tērā pea ka pā tēnei ki ngā tawhā whakangāwari ngota ngota me ētahi atu mahi ka taea te whakarerekē hei whakarei ake i te tuku rongoā me ngā āhuatanga motuhake i roto i te tinana ora.
I te nuinga o te wā ka werohia ngā rauemi whakawehewehe ki roto i te tinana o te tūroro mā roto i tētahi werohanga whakawehewehe pēhanga teitei.LnkMed, he kaihanga ngaio e arotahi ana ki te rangahau me te whakawhanake i ngā werohanga matū rerekē me ngā taonga tautoko, kua hokona e iaCT, MRI, meDSAngā werohanga i te kāinga me tāwāhi, ā, kua mōhiotia e te mākete i roto i ngā whenua maha. Ka taea e tā mātou wheketere te whakarato i ngā tautoko katoangā mea pauHe rongonui i ngā hōhipera i tēnei wā. He tino pakari ngā tikanga tirotiro kounga a tō mātou wheketere mō te whakaputa taonga, te tuku tere, me te ratonga whai muri i te hoko whānui me te whai hua. Ko ngā kaimahi katoa oLnkMedKo te tumanako ka nui ake taku whai wāhi atu ki te umanga angiography a meake nei, ka haere tonu ki te waihanga i ngā hua kounga teitei mā ngā kiritaki, me te whakarato manaaki ki ngā tūroro.
He aha tā te rangahau e whakaatu ana?
Kua whakaurua he tikanga hou ki te NCA e whakarei ake ana i te āhua whakangā roa o ngā pūmua, e āhei ai te whakaputa i ngā whakaahua koi ake i ngā kawenga iti rawa o ngā matatini gadolinium. Ka whakaitihia e te kawenga iti te mōrearea o ngā pānga kino nā te mea he iti noa te horopeta o te CA.
Nā te āhuatanga takai-ā-ia anō, he matotoru te pūtake o te SMDC, ā, he kiki hoki te taiao matatini. Ka piki ake te whakangāwari i te mea ka herea pea te nekehanga o roto me te nekehanga wāhanga huri noa i te atanga SMDC-Gd.
Ka taea e tēnei NCA te kohikohi i roto i ngā pukupuku, ka taea ai te whakamahi i te rongoā hopu neutron Gd hei rongoā i ngā pukupuku kia tino tika, kia whai hua hoki. Tae noa ki tēnei wā, kāore anō kia tutukihia tēnei i roto i te rongoā haumanu nā te korenga o te whiriwhiringa hei tuku i te 157Gd ki ngā pukupuku me te pupuri i a rātou i ngā kukū tika. Ko te hiahia ki te wero i ngā horopeta teitei e pā ana ki ngā pānga kino me ngā putanga kino nā te mea ko te nui o te gadolinium e karapoti ana i te pukupuku e tiaki ana i a ia mai i te pānga neutron.
Ka tautoko te ine nano i te kohikohinga whiriwhiri o ngā kukū rongoā me te tohatoha pai o ngā rongoā i roto i ngā pukupuku. Ka taea e ngā ngota iti te puta i ngā uaua toto, ka hua ake he mahi ārai pukupuku teitei ake.
"I te mea he iti iho i te 10 nm te whānui o te SMDC, ko te tikanga pea i ahu mai ā mātou kitenga i te urunga hōhonu o te SMDC ki roto i ngā pukupuku, e āwhina ana ki te mawhiti i te pānga tiaki o ngā neutron wera me te whakarite kia pai te horapa o ngā irahiko me ngā hihi gamma i muri i te pānga o te neutron wera."
He aha te pānga?
"Ka taea te tautoko i te whanaketanga o ngā SMDC kua arotauhia kia pai ake ai te tautuhi i te pukupuku, ahakoa e hiahiatia ana he maha ngā werohanga MRI."
"E whakaatu ana ā mātou kitenga i te kaha ki te whakatikatika i te NCA mā te hoahoa ngota ngota e takai-ake ana, ā, e tohu ana i tētahi whanaketanga nui i roto i te whakamahinga o te NCA i roto i te tātaritanga me te maimoatanga mate pukupuku."
Wā tuku: Hakihea-08-2023
