Pērā i ngā kaiwhakamahere tāone e āta whakarite ana i te rere o ngā waka i roto i ngā pokapū tāone, ka āta whakahaere ngā pūtau i te nekehanga ngota puta noa i ō rātou rohe karihi. Hei kaitiaki tatau moroiti, ka mau tonu te mana whakahaere o ngā matatini pore karihi (NPC) kua whakauruhia ki roto i te kiriuhi karihi ki tēnei tauhokohoko ngota. Kei te whakakitea e ngā mahi hou a Texas A&M Health te whiriwhiringa matatau o tēnei pūnaha, e tuku ana pea i ngā tirohanga hou mō ngā mate neurodegenerative me te whanaketanga o te mate pukupuku.
Te Aroturukitanga Hurihuri o ngā Ara Ngota
Nā te tīma rangahau a Tākuta Siegfried Musser i te Texas A&M College of Medicine i tīmata ngā rangahau mō te tere o te whakawhiti o ngā ngota i roto i te ārai kiri-rua o te karihi. Ko tā rātou pukapuka rongonui, Nature, e whakaatu ana i ngā kitenga hou i taea ai e te hangarau MINFLUX – he tikanga whakaahua matatau e taea ai te hopu i ngā nekehanga ngota 3D e puta ana i roto i ngā mirihekona i ngā tauine tata ki te 100,000 ngā wā he pai ake i te whānui o te makawe tangata. He rerekē ki ngā whakaaro o mua mō ngā ara wehe, e whakaatu ana tā rātou rangahau he rite tonu ngā ara o ngā tukanga kawemai me te kaweake karihi i roto i te hanganga NPC.
Ngā Kitenga Whakamiharo e Wero ana i ngā Tauira o nāianei
I whakaatuhia e ngā kitenga a te tīma ngā tauira waka ohorere: ka tere rua ngā ngota i roto i ngā awaawa kuiti, ka nekeneke tetahi ki tetahi, kaua ki te whai i ngā ara motuhake. He mea whakamiharo, ka kohikohi ēnei matūriki ki ngā pakitara o te awaawa, ka waiho te wāhi pokapū kia takoto kau, i te mea ka puhoi haere tō rātou ahunga whakamua – tata ki te 1,000 ngā wā ka puhoi ake i te nekehanga kore aukati – nā ngā whatunga pūmua aukati e hanga ana i tētahi taiao tirikara.
E whakaahua ana a Musser i tēnei hei "āhuatanga waka tino wero rawa atu ka taea te whakaaro - te rere rua-ara i roto i ngā ara whaiti." E whakaae ana ia, "E whakaatu ana ā mātou kitenga i tētahi huinga o ngā mea ka taea, e whakaatu ana i te uaua nui atu i tā mātou whakapae taketake i whakaarohia."
Te Whai Hua Ahakoa Ngā Ārai
He mea whakamīharo, ahakoa ēnei herenga, he tino whai hua ngā pūnaha kawe NPC. E whakapae ana a Musser, "Ko te nui o ngā NPC ka ārai pea i te mahi nui rawa, ka whakaitihia te wawaotanga whakataetae me ngā mōrearea aukati." Ko tēnei āhuatanga hoahoa ā-roto te āhua nei ka ārai i te aukati irahiko, I konei'he putanga kua tuhia anōtia me ngā momo wetereo, hanganga, me ngā wehenga paraka rerekē, me te pupuri tonu i te tikanga taketake:
Ka Huri te Huarahi o te Ngārara: Ka Whakakitea e ngā NPC ngā Ara Huna
Engari i te haere tika mā roto i te NPC'I te tuaka pokapū o te pū, te āhua nei ka whakatere ngā ngota i roto i tētahi o ngā hongere kawe motuhake e waru, ia hongere e herea ana ki tētahi hanganga rite ki te kōrero i te taha o te pūaha.'te mowhiti o waho. Ko tēnei whakaritenga ā-wāhi e tohu ana i tētahi tikanga hoahoa matua e āwhina ana ki te whakahaere i te rere o te ngota ngota.
E whakamārama ana a Musser,"Ahakoa e mōhiotia ana kei roto i ngā pūwero karihi rewena he'mono pokapū,'he mea ngaro tonu tōna hanganga tuturu. I roto i ngā pūtau tangata, kua kore tēnei āhuatanga e whai hua'kāore i kitea, engari he mea whaitake te wehewehenga mahi—me te pūwero'Tērā pea ko te pokapū s te huarahi kaweake matua mō te mRNA."
Ngā Hononga Mate me ngā Wero Whakaora
Te ngoikore o te NPC—he kuwaha pūtau nui—kua honoa ki ngā mate pūnaha io kino, tae atu ki te ALS (Lou Gehrig'te mate (s), Alzheimer's, me Huntington'te mate. Hei tāpiri, ko te pikinga ake o te mahi hokohoko NPC e hono ana ki te whanaketanga o te mate pukupuku. Ahakoa ko te arotahi ki ngā rohe pūwero motuhake ka taea te āwhina i te wetewete i ngā aukati, te whakaroa rānei i te kawe nui, e whakatūpato ana a Musser he mōrearea te whakararuraru i te mahi NPC, i runga i tōna tūranga matua i roto i te oranga o te pūtau.
"Me wehewehe tātou i waenga i ngā hapa e pā ana ki te kawe waka me ngā take e pā ana ki te NPC.'te huihuinga, te wetewete rānei,"e kī ana ia."Ahakoa he maha ngā hononga mate ka taka pea ki roto i te wāhanga whakamutunga, kei reira ngā tūponotanga—pērā i ngā whakarerekētanga ira c9orf72 i roto i te ALS, e hanga ana i ngā kohikohinga ka ārai ā-tinana i te pū kōhao."
Ngā Aronga ā-Mārama: Te Mahere i ngā Ara Utauta me te Whakaahua Pūtau Ora
Musser me tana hoa mahi a Tākuta Abhishek Sau, nō Texas A&M'te Taiwhanga Karuārai Tahi, te mahere ki te tirotiro mēnā he rerekē ngā momo utanga—pērā i ngā waeine ribosomal me te mRNA—whai i ngā ara ahurei, ka huihui rānei i ngā ara tiritahi. Tērā pea ka urutauhia e tā rātou mahi tonu me ngā hoa Tiamana (EMBL me Abberior Instruments) a MINFLUX mō te whakaahua wā-tūturu i roto i ngā pūtau ora, e tuku ana i ngā tirohanga onge mō ngā hihiri kawe karihi.
Mā te tautoko a te NIH, ka hurihia e tēnei rangahau tō tātou māramatanga ki ngā mahi kawe pūtau, e whakaatu ana me pēhea te pupuri a ngā NPC i te tikanga i roto i te tāone nui moroiti o te karihi.
Wā tuku: Maehe-25-2025
